A crash in Hopkinton, Massachusetts, temporarily closed Interstate 495 near Exit 55 Thursday afternoon.
A medical helicopter was brought in, prompting the highway to be closed, according to the Massachusetts Department of Transportation.
The cause of the crash wasn't immediately clear, and it wasn't immediately clear how many people were hurt.
Aerial footage showed wreckage in the woods near the highway.
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The highway was fully reopened after about an hour.